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Cat. Number
101363
Chemical Name
Mitoquinone | Mitochondria-targeted antioxidant
CAS Number
444890-41-9
Mol. Formula
C37H44BrO4P
Mol. Weight
663.64
Qty 1
5mg
Qty 2
25mg
Appearance
Brown waxy solid
Application Notes
98% by TLC NMR (Conforms)
Synonym
10-(6'-Ubiquinonyl)decyltriphenylphosphonium bromide
Solubility
Soluble in DMSO.
Storage condition
-20° Shipping Code: RT
Stability
Stable for 3 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
References

Mitoquinone (444890-40-9) is a mitochondria-targeted antioxidant. Displays cardio- and neuroprotective effects.1 Displays beneficial effects in mouse models of Alzheimer's disease.2 Mitoquinone protects pancreatic β-cells against oxidative stress and improves insulin secretion.3 Cell permeable.

References/Citations
1) Ghosh et al. (2010), Neuroprotection by a mitochondria-targeted drug in a Parkinson's disease model; Free Radic. Biol. Med., 49 1674
2) McManus et al. (2011), The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer's disease; J. Neurosci., 31 15703
3) Lim et al. (2011), Mitrochondria-targeted antioxidants protect pancreatic β-cells against oxidative stress and improve insulin secretion in glucotoxicity and glucolipotoxicity; Cell Physiol. Biochem., 28 873
4) Demers-Lamarche et al. (2016) Loss of Mitochondrial Function Impairs Lysosomes; J. Biol. Chem. 291 10263 [Focus Citation]
5) Zhou et al. (2018) Mitochondrial-targeted antioxidant MitoQ provides neuroprotection and reduces neuronal apoptosis in experimental traumatic brain injury possibly via the Nrf2-ARE pathway; Am. J. Transl. Res., 10 1887 [Focus Citation]
6) Xiao et al. (2017) The mitochondrial-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1; Redox Biol., 11 297 [Focus Citation]
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