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Cat. Number
10-2567
Chemical Name
10-2567 (15R)-17-Demethoxy-15 methoxy-11-O-methyl-geldanamycin 70563-58-5
CAS Number
70563-58-5
Mol. Formula
C30H42N2O9
Mol. Weight
574.68
Qty 1
100 µg
Qty 2
1mg
Appearance
Yellow lyophilized solid
Application Notes
98% by TLC NMR (Conforms)
Synonym
(15R)-17-Demethoxy-15 methoxy-11-O-methyl-geldanamycin
Solubility
Soluble in DMSO (up to 6 mg/ml).
Storage condition
RT
Stability
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
References

Herbimycin A (70563-58-5) is an ansamycin antibiotic. Inhibits HSP90 and associated client proteins including v-Src, Bcr-Abl, Raf-1 and ErbB21,2. Herbimycin A reverts tyrosine kinase-induced oncogenic transformation without direct inhibition of phosphorylation activity1. Inhibits angiogenesis in a rat retinopathy model3.

References/Citations - Herbimycin A
1) Whitesell et al. (1994), Inhibition of heat shock protein HSP-90-pp60vsrc heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation; Proc. Natl. Acad. Sci. USA, 91 8324
2) Blagosklonny et al. (2002), Hsp-90-associated oncoproteins: multiple targets of geldanamycin and it's analogs; Leukemia, 16 455
3) GW McCollum et al. (2004), Herbimycin A inhibits angiogenic activity in endothelial cells and reduces neovascularization in a rat model of retinopathy of prematurity; Exp. Eye Res., 78 987

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Herbimycin A,货号10-1011 上海惠诚提供100µg 1mg Herbimycin A,美国focus原装进口,咨询电话021-60498804

Herbimycin A,货号10-1011 上海惠诚提供100µg 1mg Herbimycin A,美国focus原装进口,咨询电话021-60498804

 

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