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| Cat. Number | 10-2458 |
| Chemical Name | 10-2458 1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile hydrobromide 59729-32-7 |
| CAS Number | 59729-32-7 |
| Mol. Formula | C20H21FN2O HBr |
| Mol. Weight | 405.31 |
| Qty 1 |
50mg |
| Qty 2 | 250mg |
| Appearance | White solid |
| Application Notes | 98% by TLC NMR (Conforms) |
| Synonym | 1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile hydrobromide |
| Solubility | Soluble in Water (up to 4 mg/ml), DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml) |
| Storage condition | -20°C (des.) |
| Stability | Stable for 2 years as supplied. Solutions in water, DMSO or ethanol may be stored at -20°C for up to 2 months. |
| References | Citalopram (59729-32-7) is a potent and selective serotonin uptake inhibitor (SSRI) Ki=5.4 nM. Has no effect on norepinephrine or dopamine uptake.1 Displays cardioprotective effects in part by reducing expression of cytokine-induced endothelial adhesion molecules, ICAM-1 and VCAM-1.2 Clinically useful antidepressant.3 Attenuates ethanol intake.4
References/Citations
1) Mateo et al. (2000), Inhibition of 5-hydroxytryptamine reuptake by the antidepressant citalopram in the locus coeruleus modulates the rat brain noradrenergic transmission in vivo; Neuropharmacology 39 2036
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