您的位置:首页>>生化试剂>>小分子化合物>>10-2295 3-Methyl-1-phenyl-2-pyrazolin-5-one Molecular Weight: 174.2 Molecular 89-25-8
Cat. Number
10-2295
Chemical Name
10-2295 3-Methyl-1-phenyl-2-pyrazolin-5-one Molecular Weight: 174.2 Molecular 89-25-8
CAS Number
89-25-8
Mol. Formula
C10H10N2O
Mol. Weight
174.2Soluble in DMSO (up to 20 mg/ml).
Qty 1
50mg
Qty 2
1g
Appearance
Tan solid
Application Notes
98% by TLC NMR (Conforms)
Synonym
Edaravone
Solubility
Soluble in DMSO (up to 20 mg/ml).
Storage condition
RT (des.)
Stability
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
References

MCI-186 (89-25-8), also known as edaravone,  is an antioxidant free radical scavenger used as a neuroprotective agent following acute brain ischemia and subsequent cerebral infarction.1,2 MCI-186 also protects against MPTP-induced neurotoxicity in the Substantia Nigra.3

References/Citations
1) Watanabe et al. (1994), Protective effects of MCI-186 on cerebral ischemia:possible involvement of free radical scavenging and antioxidant actions; J. Pharmacol. Exp. Ther., 268 1597
2) Yoshida et al. (2006) Neuroprotective effects of edaravone:a novel free radical scavenger in cerebrovascular injury; CNS Drug Reviews, 12 9
3) Kawasaki et al. (2007) Edaravone (3-Methyl-1-phenyl-2-pyrazolin-5-one), a Radical Scavenger, Prevents 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Neurotoxicity in the Substantia Nigra but Not the Striatum; J. Pharmacol. Exp. Ther., 322 274

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