HMF102187 (9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid 34157-83-0

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Cat. Number

HMF102187

Chemical Name

HMF102187 (9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid 34157-83-0

CAS Number

34157-83-0

Mol. Formula

C29H38O4

Mol. Weight

450.62

Qty 1

50mg

Qty 2

100mg

Appearance

Red Solid

Application Notes

98% by TLC NMR (Conforms)

Synonym

(9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid

Solubility

Soluble in DMSO (up to 45 mg/ml) or in Ethanol (up to 30 mg/ml).

Storage condition

-20℃

Stability

Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.

References

雷公藤红素 Celastrol (34157-83-0)显示出强大的抗氧化和抗炎活性。抑制NFkB (IC50=270 nM)。它能诱导多种细胞的热休克反应和细胞保护作用。抑制20S蛋白酶体胰凝乳酶活性(IC50=2.5 mM)。靶向AR/miR-101诱导前列腺癌细胞自噬在癌细胞中诱导upr依赖性细胞死亡细胞的渗透。雷公藤红素是一种蛋白酶体抑制剂，有效且优先抑制20S 蛋白酶体的胰凝乳蛋白酶样活性，IC50 为2.5 μM。

订购信息:

10 mg	￥880	In-stock
50 mg	￥2520	In-stock
100 mg	￥3375	In-stock

产品信息：

CAS:	34157-83-0
Activity:	Proteasome inhibitor
Chemical Name:	(9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid
Molecular Weight:	450.62
Molecular Formula:	C29H38O4
Solubility:	Soluble in DMSO or in Ethanol.
Physical Properties:	Red Solid
Purity:	98%
Storage Temperature:	-20°
Stability:	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months.