您的位置:首页>>生化试剂>>小分子化合物>>10-2152 4-Methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide 641571-10-0
Cat. Number
10-2152
Chemical Name
10-2152 4-Methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide 641571-10-0
CAS Number
641571-10-0
Mol. Formula
C28H22F3N7O
Mol. Weight
529.52
Qty 1
10mg
Qty 2
50mg
Appearance
Off-white solid
Application Notes
98% by TLC NMR (Conforms)
Synonym
AMN-107
Solubility
Soluble in DMSO (up to 50 mg/ml)
Storage condition
-20℃
Stability
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
References

A novel, selective BCR-ABL inhibitor.  More potent than imatinib against wild-type BCR-ABL (IC50 < 30 nM)1. Induces apoptosis2.

References/Citations

1) Weisberg et al. (2006), AMN107 (nilotinib): a novel and selective inhibitor of BCR-ABL; Br J. Cancer, 94 1765
2) Verstovsek et al. (2006), Activity of AMN107, a novel aminopyrimidine tyrosine kinase inhibitor, against human FIP1L1-PDGFR-alpha-expressing cells; Ann. Neurol., 75 209

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