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| Cat. Number | 10-2148 |
| Chemical Name | 10-2148 (R,S)-3-(4-Amino-1-oxo-3H-isoindol-2-yl)piperidine-2,6-dione 191732-72-6 |
| CAS Number | 191732-72-6 |
| Mol. Formula | C13H13N3O3 |
| Mol. Weight | 259.26 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Appearance | White solid |
| Application Notes | 98% by TLC NMR (Conforms) |
| Synonym | (R,S)-3-(4-Amino-1-oxo-3H-isoindol-2-yl)piperidine-2,6-dione |
| Solubility | Soluble in DMSO (up to 30 mg/ml) |
| Storage condition | RT (des.) |
| Stability | Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| References | Lenalidomide (191732-72-6) is a thalidomide analog which, like thalidomide1, binds to cereblon which is the substrate recognition component of a cullin-dependent ubiquitin ligase and inhibits its autoubiquitination activity2. Induces degradation of T-cell repressors Ikaros (IKZF1) and Aiolos (IKZF3) leading to T cell activation.2 Selective inhibition of IKZF1 and IKZF3 by lenalidomide in multiple myeloma cells results in cell death.3,4 Cell permeable. Caution: Teratogenic References/Citations
1) Ito et al. (2010), Identification of a primary target of thalidomide teratogenicity; Science, 327 1345
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