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| Cat. Number | 10-2146 |
| Chemical Name | 10-2146 (S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]-indolizino[1,2-b]quinolin-9-yl-[1,4'-bipiperidine]-1'-carboxylate hydrochloride 136572-09-3 |
| CAS Number | 136572-09-3 |
| Mol. Formula | C33H38N4O6 HCl 3H20 |
| Mol. Weight | 677.2 |
| Qty 1 |
50mg |
| Qty 2 | 250mg |
| Appearance | Yellow solid |
| Application Notes | 98% by TLC NMR (Conforms) |
| Synonym | (S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]-indolizino[1,2-b]quinolin-9-yl-[1,4'-bipiperidine]-1'-carboxylate hydrochloride |
| Solubility | Soluble in DMSO (up to 50 mg/ml), in Water (up to 4 mg/ml) or in Ethanol (up to 4 mg/ml). |
| Storage condition | -20℃ |
| Stability | Stable for 1 year as supplied. Solutions in DMSO, ethanol or distilled water may be stored at -20° for up to 3 months. |
| References | Irinotecan (136572-09-3) is a semi-synthetic derivative of camptothecin (Cat.# 10-1041) that is an FDA approved anticancer drug. It is a prodrug that is converted by tissue esterases to 7-ethyl-10-hydroxycamptothecin (SN-38, Cat.# 10-2425), a potent inhibitor of DNA topoisomerase I.1,2 Although irinotecan is also a topoisomerase inhibitor, SN-38 is approximately 1000 times as potent in purified enzyme studies. In vitro cytotoxicity assays show much greater variability in potency between the two (2-2000 fold).3
References/Citations
伊立替康HCl 英文名称Irinotecan HCl ，货号10-2146 上海惠诚提供250mg 50mg 伊立替康HCl Irinotecan HCl，美国focus原装进口，咨询电话021-60498804 |
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