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Cat. Number
10-2084
Chemical Name
细霉素B. Leptomycin B
CAS Number
87081-35-4
Mol. Formula
C33H48O6
Mol. Weight
540.75
Qty 1
200µg
Qty 2
1mg
Application Notes
99% by HPLC NMR (Conforms)
Solubility
Supplied in solution in ethanol (1 mg/ml). Further dilutions may be made with either ethanol or DMSO.
Storage condition
-20℃
Stability
Stable for 1 year as supplied. Solutions or dilutions in DMSO are not stable. Solutions should be made fresh and used within one working day.
References

Leptomycin B (87081-35-4) is an inhibitor of nuclear export of proteins. Acts via covalent binding to and inhibiting CRM1/exportin-11. Inhibits the nuclear export of the HIV regulatory protein Rev2. Leptomycin B stabilizes p53 by blocking its nuclear export3.

References/Citations
1) Kudo et al. (1998), Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1; Exp. Cell Res., 242 540
2) Wolff et al. (1997), Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA; Chem. Biol., 4 139
3) Freedman and Levine (1998), Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6; Mol. Cell. Biol., 18 7288

Focus Biomolecules supplier, chemical structure of Leptomycin B | Nuclear export inhibitor | CAS 87081-35-4

细霉素B.  英文名称Leptomycin B ，货号10-2084 上海惠诚提供200µg 1mg细霉素B. Leptomycin B，美国focus原装进口，咨询电话021-60498804
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