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Cat. Number
10-1126
Chemical Name
长春西汀 Vinpocetine
CAS Number
42971-09-5
Mol. Formula
C22H26N2O2
Mol. Weight
350.45
Qty 1
20mg
Qty 2
100mg
Appearance
White solid
Application Notes
98% by TLC NMR (Conforms)
Synonym
(3α,16α)-Eburnamenine-14-carboxylic acid ethyl ester
Solubility
Soluble in DMSO (up to 5 mg/ml), in ethanol (up to 15 mg/ml) or in DMF (up to 3 mg/ml with warming)
Storage condition
RT
Stability
Stable for 1 year as supplied. Solutions in DMSO, Ethanol, or DMF may be stored at -20°C for up to 3 months.
References

Vinpocetine (42971-09-5) is a phosphodiesterase PDE1 inhibitor (IC50=21 μM).1 Also blocks voltage-gated Na+ channels, IC50=44.2 μM (potency similar to phenytoin), a mechanism which may contribute to its neuroprotective and anticonvulsant activity.2 It reduces inflammatory IL-1β and TNF-α expression in rat hippocampus.3Displays beneficial effects in a rat model of cerebral ischemia-reperfusion injury.4Vinpocetine exerts neuroprotective effects by suppressing microglial inflammation.5

References/Citations

1) Hagiwara et al. (1984), Effects of vinpocetine on cyclic nucleotide metabolism in vascular smooth muscle; Biochem. Pharmacol., 33 453
2) Molnar and Erdo (1995), Vinpocetine is as potent as phenytoin to block voltage-gated Na+ channels in rat cortical neurons; Eur. J. Pharmacol., 273 303
3) Gomez et al. (2014), The anti-seizure drugs vinpocetine and carbamazepine, but not valproic acid, reduced inflammatory IL1β and TNF-α expression in rat hippocampus; J. Neurochem., 130 770
4) Wang et al. (2014), Anti-inflammatory effects of vinpocetine on the functional expression of nuclear factor-kappa B and tumor necrosis factor-alpha in a rat model of cerebral ischemia-reperfusion injury; Neuro. Sci. Lett., 566 247
5) Zhao et al. (2011), TSPO-specific ligand vinpocetine exerts a neuroprotective effect by suppressing microglial inflammation; Glia Biol., 7 187

Vinpocetine | 42971-09-5 | Structure | Supplier

长春西汀  英文名称Vinpocetine ,货号10-1126 上海惠诚提供100mg 20mg 长春西汀 Vinpocetine,美国focus原装进口,咨询电话021-60498804

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