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| Cat. Number | A5132 |
| Chemical Name | 阿米卡星二硫酸盐 Amikacin Disulfate |
| CAS Number | 39831-55-5 |
| Mol. Formula | C22H43N5O13 • 2H2SO4 |
| Mol. Weight | 781.76 |
| Qty 1 |
250mg |
| Qty 2 | 1g |
| Application Notes | ≥98% |
| Synonym | Amikacin sulfate, Amikin, Biklin, Lukadin, Mikavir, Novamin, Pierami,O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1->6)-O- [6-amino-6-deoxy-α-D-glucopyranosyl-(1->4)]-N1- [(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-D- streptamine sulfate |
| Melting Pt. | 220-230°C(dec.) |
| Solubility | oluble in water (50mg/mL). Insolulble in acetone and water. DMSO <1 mg/mL. |
| Storage condition | Ambient |
| References | Amikacin is an aminoglycoside antibiotic that exhibits antibacterial efficacy against gram negative bacteria. Amikacin binds the 30S ribosomal subunit, preventing translation. 参考文献： Barza M, Scheife RT. Drug therapy reviews: Antimicrobial spectrum, pharmacology and therapeutic use of antibiotics--part 4: aminoglycosides. Am J Hosp Pharm. 1977 Jul;34(7):723-37. PMID: 407790. Kawaguchi H. Discovery, chemistry, and activity of amikacin. J Infect Dis. 1976 Nov;134 SUPPL:S242-8. PMID: 825583. King P, Citron DM, Griffith DC, et al. Effect of oxygen limitation on the in vitro activity of levofloxacin and other antibiotics administered by the aerosol route against Pseudomonas aeruginosa from cystic fibrosis patients. Diagn Microbiol Infect Dis. 2010 Feb;66(2):181-186. PMID: 19828274. |
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