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| Cat. Number | 1072 |
| Chemical Name | 1072 10191-41-0 rac-α-生育酚 rac-alpha-Tocopherol |
| CAS Number | 10191-41-0 |
| Mol. Formula | C29H50O2 |
| Mol. Weight | 431 |
| Qty 1 |
1ml |
| Qty 2 | 50mg/ml |
| Appearance | liquid |
| Application Notes | TLC 95%;GC 98%, HPLC 98%,TLC, GC, HPLC; identity confirmed by MS |
| Synonym | rac-α-生育酚 rac-alpha-Tocopherol,5,7,8-Trimethyltocol |
| Solubility | methanol, ethanol, hexane, chloroform |
| Storage condition | -20℃ |
| References | Application Notes: Alpha-tocopherol is one of the eight forms of vitamin E and contains three methyl groups attached to the chromonal ring. Of all the forms of vitamin E, alpha-tocopherol is preferentially retained by the liver in animals and undergoes slower catabolism in cells. It has been found that alpha-tocopherol inhibits the activity of protein kinase C, an enzyme involved in cell proliferation and differentiation in smooth muscle cells, platelets, and monocytes. Other functions of alpha-tocopherol include gene regulation, up-regulation of mRNA or protein synthesis, and preventing the uptake of the harmful 7- hydroxycholesterol into cells.1 Although the antioxidant activity of alpha-tocopherol in vitro has long been established it appears that this may not be one of its primary functions in vivo.2 Vitamin E is involved in immune function, cell signaling, regulation of gene expression, and other metabolic processes. Vitamin E also inhibits lipid oxidation by donating its phenolic hydrogen to lipid free radicals.3 Antioxidant activity in vivo is normally alpha>beta>delta>gamma but the antioxidant potency may depend on various chemical and physical situations.4 The ortho-methyl substitution of the chroman head plays a vital role in the antioxidant activity of tocopherols while the phytyl tail is very important for proper positioning in the biomembranes. The antioxidant properties of vitamin E may delay memory loss in Down’s syndrome patients due to their protection from harmful oxidation caused by excess activity of superoxide dismutase. Vitamin E is only naturally produced in plants, algae, and some cyanobacteria and is therefore an important dietary nutrient for humans and animals.
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