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Cat. Number
TFA-氨基修饰 CPG 500 TFA-Amino modifier CPG 500
Chemical Name
TFA-氨基修饰 CPG 500 TFA-Amino modifier CPG 500
Qty 1
250mg
Qty 2
500mg
Appearance
off-white beads
Storage condition
-20°C
References

This high load, 500 Å controlled pore glass solid support is designed for the synthesis of oligonucleotides containing up to 50 bases with a 3'-amino group. Amino group is protected with trifluoroacetyl (TFA) protection which is easily removed under standard deblock conditions.

The reagent is based on hydroxyprolinol core - a universal non-nucleoside structure that is naturally 100% chiral (no isomers formed upon condensation), and stable to all conditions of oligonucleotide synthesis and deblock.

TFA-amino modifier CPG structure

Oligo synthesis details

Pore size, Å: 500
Typical loading, umol/g: 70−90
Coupling conditions: standard coupling, identical to normal nucleobases
Cleavage conditions: ammonia, 2 h at room temperature
Deprotection conditions: identical to protected nucleobases
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