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Cat. Number
Cyanine5 azide
Chemical Name
Cyanine5 azide
Mol. Formula
C35H45ClN6O
Mol. Weight
601.22
Qty 1
5mg
Qty 2
10mg
Appearance
dark blue powder / solution
Storage condition
-20°C
References

Cyanine5 azide labeling reagent for Click Chemistry, available as 10 mM solution in DMSO, and in solid form.

This azide is soluble in organic solvents (e.g. DMSO, DMF), therefore the labeling reaction should be carried out with a small amount of an organic co-solvent. This azide can be used for the labeling of alkyne-modified biomolecules in mixtures of water with organic solvents. The solution in DMSO is ready for use in bioconjugation. A water-soluble sulfonated version of this reagent is also available.

Cyanine5 is an analog of Cy5®, one of the most commonly used fluorophores which is compatible with various instruments. Cyanine5 can also be used as a replacement for Alexa Fluor® 647, and DyLight® 649.

Product citations

  1. Shabanpoor, F.; Hammond, S.M.; Abendroth, F.; Hazell, G.; Wood, M.J.A.; Gait, M.J. Identification of a Peptide for Systemic Brain Delivery of a Morpholino Oligonucleotide in Mouse Models of Spinal Muscular Atrophy. Nucleic Acid Therapeutics, in press. doi:10.1089/nat.2016.0652

  2. Louage, B.; Tack, L.; Wang, Y.; De Geest, B.G. Poly(glycerol sebacate) nanoparticles for encapsulation of hydrophobic anti-cancer drugs. Polymer Chemistry, in press. doi: 10.1039/c6py02192a

  3. Cho, W.; Koo, J.Y.; Park, Y.; Oh, K.; Lee, S.; Song, J.-S.; Bae, M.A.; Lim, D.; Lee, D.-S.; Park, S.B:. Treatment of Sepsis Pathogenesis with High Mobility Group Box Protein 1-Regulating Anti-inflammatory Agents. Journal of Medicinal Chemistry, 2017, 60(1), 170–179. doi: 10.1021/acs.jmedchem.6b00954

  4. Fiacco, S.V.; Kelderhouse, L.E.; Hardy, A.; Peleg, Y.; Hu, B.; Ornelas, A.; Yang, P.; Gammon, S.T.; Howell, S.M.; Wang, P.; Takahashi, T.T.; Millward, S.W.; Roberts, R.W. Directed Evolution of Scanning Unnatural-Protease-Resistant (SUPR) Peptides for in Vivo Applications. Chembiochem, 2016, 17(17), 1643–1651. doi: 10.1002/cbic.201600253
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