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Cat. Number
450743265344407
Chemical Name
N-Dodecanoyl-NBD-L-threo-dihydrosphingosine
Category
synthetic
Mol. Formula
C36H63N5O6
Mol. Weight
662
Qty 1
1mg
Appearance
solid
Application Notes
98+% TLC
Synonym
N-C12:0-NBD-Dihydroceramide; N-C12:0-NBD-L-threo-Dihydrosphingosine
Solubility
methanol, chloroform/methanol, 2:1
Storage condition
-20°C
References

1. Darges, et al. “Inhibition of leukotriene B4 (LTB4) in human neutrophils by L-threo-dihydrosphingosine” Adv. Exp. Med. Biol, Vol. 400A pp. 387-392, 1997
2. G. Schwartz, et al. “A pilot clinical/pharmacological study of the protein kinase C-specific inhibitor safingol alone and in combination with doxorubicin” Clin. Cancer Res, Vol. 3 pp. 537-543, 1997
3. J. Coward et al. “Safingol (L-threo-sphinganine) induces autophagy in solid tumor cells through inhibition of PKC and the PI3-kinase pathway” Autophagy Vol. 5(2) pp.184-193, 2009
4. M. Dragusin et al. “Metabolism of the unnatural anticancer lipid safingol,L-threo-dihydrosphingosine, in cultured cells” Vol. 44 pp. 1772, 2003
下一个：N-十七酰基-D-赤式-鞘氨醇 N-Heptadecanoyl-D-erythro-sphingosine上一个：Main phospholipid (MPL) of Thermoplasma acidophilum (>95% pure)
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