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| Cat. Number | H1755 |
| Chemical Name | H1755 D,L-erythro-PDMP 109760-77-2 |
| CAS Number | 109760-77-2 |
| Category | synthetic |
| Mol. Formula | C23H38N2O3•HCl |
| Mol. Weight | 427 |
| Qty 1 |
100mg |
| Appearance | solid |
| Application Notes | 98+% TLC; HPLC; identity confirmed by MS |
| Synonym | D,L-erythro-1-Phenyl-2-decanoylamino-3-morpholino-1-propanol•HCl |
| Solubility | ethanol, methanol, chloroform, DMSO |
| Storage condition | -20°C |
| References | D,L-erythro-PDMP inhibits the growth of cells, including cancer cells. D-threo-PDMP has been shown to inhibit cell growth by inhibiting the enzyme glucosylceramide synthase1 but erythro-PDMP inhibits growth according to a different mechanism. PDMP has four possible isomers (D-threo, L-threo, D-erythro, and L-erythro) due to its two chiral centers. This product (D,L-erythro-PDMP) is a mixture of D-erythro (1R,2R) and L-erythro (1S,2S). The D-threo isomer has been shown to be the active glucosyl ceramide synthetase inhibitor.2 Although erythro-PDMP does not inhibit glucosylceramide synthase it does cause cell growth inhibition similar to threo-PDMP.3 This has been suggested as a treatment for cancer.4 In addition to its stereochemistry, the acyl chain of PDMP has a very marked effect on the intensity of the inhibitory action of the molecule. |
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