H1889 环己烯四醇β环氧化物，Conduritol B Epoxide 6090-95-5_上海惠诚生物生物试剂,标准品,仪器设备,耗材,一站式服务

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Cat. Number	H1889
Chemical Name	H1889 环己烯四醇β环氧化物，Conduritol B Epoxide 6090-95-5
CAS Number	6090-95-5
Category	synthetic
Mol. Formula	C₆H₁₀O₅
Mol. Weight	162
Qty 1	25mg
Appearance	solid
Application Notes	98+% TLC, NMR
Synonym	Inhibits alpha-glucosidase activity; specific inhibitor of glucocerebrosidase in cultured cells
Solubility	water, DMSO, methanol (slightly)
Storage condition	-20°C
References	1. G. Grabowski et al. “Gaucher disease types 1, 2, and 3: differential mutations of the acid beta-glucosidase active site identified with conduritol B epoxide derivatives and sphingosine” Am J Hum Genet., Vol. 37 pp. 499-510, 1985 2. S. Yang et al. “Inactivation of alpha-glucosidase by the active-site-directed inhibitor, conduritol B epoxide” Biochim Biophys Acta, Vol. 828(3) pp. 236- 240, 1985 3. L. Premkumar et al. “X-ray Structure of Human Acid-beta-Glucosidase Covalently Bound to Conduritol-B-Epoxide Implications for Gaucher Disease” The Journal of Biological Chemistry, Vol. 280(25) pp. 23815-23819, 2005 4. G. Grabowski et al. “Human acid beta-glucosidase. Use of conduritol B epoxide derivatives to investigate the catalytically active normal and Gaucher disease enzymes” The Journal of Biological Chemistry, Vol. 261(18) pp. 8263-8269, 1986 5. E. Korkotian et al. “Elevation of Intracellular Glucosylceramide Levels Results in an Increase in Endoplasmic Reticulum Density and in Functional Calcium Stores in Cultured Neurons” The Journal of Biological Chemistry, Vol. 274(31) pp. 21673-21678, 1999
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