您的位置:首页>>分析化学>>脂类分析标准品>>H1889 环己烯四醇β环氧化物,Conduritol B Epoxide 6090-95-5
Cat. Number
H1889
Chemical Name
H1889 环己烯四醇β环氧化物,Conduritol B Epoxide 6090-95-5
CAS Number
6090-95-5
Category
synthetic
Mol. Formula
C6H10O5
Mol. Weight
162
Qty 1
25mg
Appearance
solid
Application Notes
98+% TLC, NMR
Synonym
Inhibits alpha-glucosidase activity; specific inhibitor of glucocerebrosidase in cultured cells
Solubility
water, DMSO, methanol (slightly)
Storage condition
-20°C
References

1. G. Grabowski et al. “Gaucher disease types 1, 2, and 3: differential mutations of the acid beta-glucosidase active site identified with conduritol B epoxide derivatives and sphingosine” Am J Hum Genet., Vol. 37 pp. 499-510, 1985
2. S. Yang et al. “Inactivation of alpha-glucosidase by the active-site-directed inhibitor, conduritol B epoxide” Biochim Biophys Acta, Vol. 828(3) pp. 236- 240, 1985
3. L. Premkumar et al. “X-ray Structure of Human Acid-beta-Glucosidase Covalently Bound to Conduritol-B-Epoxide Implications for Gaucher Disease” The Journal of Biological Chemistry, Vol. 280(25) pp. 23815-23819, 2005
4. G. Grabowski et al. “Human acid beta-glucosidase. Use of conduritol B epoxide derivatives to investigate the catalytically active normal and Gaucher disease enzymes” The Journal of Biological Chemistry, Vol. 261(18) pp. 8263-8269, 1986
5. E. Korkotian et al. “Elevation of Intracellular Glucosylceramide Levels Results in an Increase in Endoplasmic Reticulum Density and in Functional Calcium Stores in Cultured Neurons” The Journal of Biological Chemistry, Vol. 274(31) pp. 21673-21678, 1999

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