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Cat. Number
H1850
Chemical Name
H1850 N-硬脂酰-L-赤式-神经鞘氨醇 N-Octadecanoyl-L-erythro-sphingosine
Category
synthetic
Mol. Formula
C36H71NO3
Mol. Weight
566
Qty 1
1mg
Appearance
solid
Application Notes
98+% TLC, GC
Synonym
N-C18:0-L-erythro-Ceramide; N-Stearoyl-L-erythro-sphingosine
Solubility
chloroform, ethanol, DMSO, DMF (up to 5mg/ml)
Storage condition
-20°C
References

1. N. S. Radin, “Killing tumours by ceramide-induced apoptosis: a critique of available drugs” Biochemical Journal, Vol. 371 pp. 243-256, 2003
2. Y. Hannun et al. “Stereoselectivity of Induction of the Retinoblastoma Gene Product (pRb) Dephosphorylation by D-erythro-Sphingosine Supports a Role for pRb in Growth Suppression by Sphingosine” Biochemistry, vol. 34 pp. 1885-1892, 1995
3. W. Jarvis et al. “Induction of Apoptosis and Potentiation of Ceramide-mediated Cytotoxicity by Sphingoid Bases in Human Myeloid Leukemia Cells” The Journal of Biological Chemistry, Vol. 271 pp. 8275-8284, 1996
4. C. Chalfant et al. “Long Chain Ceramides Activate Protein Phosphatase-1 and Protein Phosphatase-2A Activation is Stereospecific and Regulated by Phosphatidic Acid” The Journal of Biological Chemistry, Vol. 274 pp. 20313-20317, 1999
5. S. Laulederkind et al. “Ceramide Induces Interleukin 6 Gene Expression in Human Fibroblasts” The Journal of Experimental Medicine, Vol. 182 pp. 599-604, 1995
6. T. Ariga et al. “Role of sphingolipid-mediated cell death in neurodegenerative diseases” Journal of Lipid Research, Vol. 39 pp. 1-16, 1998
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