| References |
| Formal Name |
5-[(1Z)-2-(3,5-dimethoxyphenyl)ethenyl]-2-methoxy-phenol |
| CAS Number |
586410-08-4 |
| Molecular Formula |
C17H18O4 |
| Formula Weight |
286.3 |
| Formulation |
A solution in methyl acetate |
| Purity |
≥98% |
| Stability |
1 year |
| Storage |
-20°C |
| Shipping |
Wet ice
in continental US; may vary elsewhere
|
| SMILES |
COc1cc(\C=C\c2ccc(OC)c(O)c2)cc(OC)c1
|
Background Reading
Roberti, M., Pizzirani, D., Simoni, D., et al. Synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents. J Med Chem 46 3546-3554 (2003).
| Size |
Global Purchasing |
| 1 mg |
|
| 5 mg |
|
| 10 mg |
|
| 25 mg |
|
Description
Resveratrol is a natural polyphenolic antioxidant that has anti-cancer properties. CAY10616 is an analog of resveratrol which is a potent inducer of apoptosis in promyelocytic leukemia HL-60 cells (IC50 = 40 nM versus 50 μM for resveratrol).1 In addition, CAY10616 induces apoptosis (IC50 = 30 nM) in HL60R, a cell line derived from HL-60 that expresses a multidrug-resistance phenotype (resistant to daunorubicin, etoposide, and citarabine).1
1
Roberti, M., Pizzirani, D., Simoni, D., et al. Synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents. J Med Chem 46 3546-3554 (2003).
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