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Cat. Number
080609107291139
Chemical Name
Ebselen
References
Formal Name 2-​phenyl-​1,​2-​benzisoselenazol-​3(2H)-​one
CAS Number 60940-34-3
Molecular Formula C13H9NOSe
Formula Weight 274.2
Formulation A crystalline solid
Purity >99%
λmax 230, 263, 330 nm
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES O=c1c2ccccc2[se]​n1c1ccccc1

Background Reading

Parnham, M.J., and Graf, E. Seleno-organic compounds and the therapy of hydroperoxide-linked pathological conditions. Biochem Pharmacol 36 3095-3102 (1987).

Parnham, M.J., and Kindt, S. A novel biologically active seleno-organic compound-III. Effects of PZ 51 (ebselen) on glutathione peroxidase and secretory activities of mouse macrophages. Biochem Pharmacol 33 3247-3250 (1984).

Maiorino, M., Roveri, A., Coassin, M., et al. Kinetic mechanism and substrate specificity of glutathione peroxidase activity of ebselen (PZ51). Biochem Pharmacol 37 2267-2271 (1988).

Masumoto, H., Kissner, R., Koppenol, W.H., et al. Kinetic study of the reaction of ebselen with peroxynitrite. FEBS Lett 398 179-182 (1996).

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Description

Ebselen acts as a glutathione peroxidase mimic and is an excellent scavenger of peroxynitrite with a rate constant of 2 x 106 M−1s−1.1 The glutathione peroxidase-like activity of ebselen inhibits cyclooxygenase and lipoxygenases at micromolar concentrations.2,3

1 Masumoto, H., Kissner, R., Koppenol, W.H., et al. Kinetic study of the reaction of ebselen with peroxynitrite. FEBS Lett 398 179-182 (1996).

2 Parnham, M.J., and Graf, E. Seleno-organic compounds and the therapy of hydroperoxide-linked pathological conditions. Biochem Pharmacol 36 3095-3102 (1987).

3 Parnham, M.J., and Kindt, S. A novel biologically active seleno-organic compound-III. Effects of PZ 51 (ebselen) on glutathione peroxidase and secretory activities of mouse macrophages. Biochem Pharmacol 33 3247-3250 (1984).

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