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Cat. Number

080426821604023

Chemical Name

Mn(III)TMPyP

References

Formal Name	Mn(III)tetrakis(1-methyl-4-pyridyl)porphyrin pentachloride
Molecular Formula	C₄₄H₃₆MnN₈ · 5Cl
Formula Weight	909.0
Formulation	A crystalline solid
Purity	>95%
λ_max	455 nm
Stability	1 year
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	C[n]1ccc(cc1)C1=c2ccc3C(=c4ccc5=C(c6cc[n](C)cc6)c6ccc7=C(c8cc[n](C)cc8)c8ccc1n8[Mn]([n]23)([n]67)n45)c1cc[n](C)cc1

Background Reading

Hunt, J., Lee, J., and Groves, J.T. Amphiphilic peroxynitrite decomposition catalysts in liposomal assemblies. Chem Biol 4 845-858 (1997).

Faulkner, K.M., Liochev, S.I., and Fridovich, I. Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo. J Biol Chem 269 23471-23476 (1994).

Size	Global Purchasing
10 mg
25 mg
50 mg
100 mg

Description

Mn(III)TMPyP is a manganese-porphyrin which acts as a superoxide dismutase (SOD) mimetic and peroxynitrite decomposition catalyst.¹ SOD mimetics described to date are unstable and are capable of catalyzing undesired side-reactions in addition to the dismutation of the superoxide radical (O₂-). Mn(III)TMPyP is an SOD mimetic with increased stability to pH and hydrogen peroxide. The rate constant for superoxide dismutation and peroxynitrite decomposition are 3.9 x 107 M⁻¹s⁻¹ and ~2 x 106 M⁻¹s⁻¹, respectively.^1,2 Mn(III)TMPyP protected and enhanced the growth of SOD null E. coli with a doubling time of 60 minutes (as compared to 240 minutes of the control) at 25 µM.²

1 Hunt, J., Lee, J., and Groves, J.T. Amphiphilic peroxynitrite decomposition catalysts in liposomal assemblies. Chem Biol 4 845-858 (1997).

2 Faulkner, K.M., Liochev, S.I., and Fridovich, I. Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo. J Biol Chem 269 23471-23476 (1994).

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