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Cat. Number
070545388088919
Chemical Name
HCN1 Cyclic Nucleotide-gated Channel Monoclonal Antibody (Clone S70-28)
References
Formulation 100 µg of protein G-purified IgG in 100 µl PBS, pH 7.4, containing 50% glycerol and 0.09% sodium azide
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Specificity
Human HCN1 +
Murine HCN1 +
Rat HCN1 +

Background Reading

Zong, X., Eckert, C., Yuan, H., et al. A novel mechanism of modulation of hyperpolarization-activated cyclic nucleotide-gated channels by src kinase. J Biol Chem 280(40) 34224-34232 (2005).

. What are ion channels? (2004).

Hille, B. Ion Channels of Excitable Membranes. 3rd (2001).

Size Global Purchasing
100 µg  

Description

Antigen: fusion protein amino acids 778-910 (cytoplasmic C-terminus) of rat HCN1 · Clone designation: S70-28 · Host: mouse · Isotype: IgG1 · Application(s): WB, IP, IHC, and ICC · Hyperpolarization-activated cation channels of the HCN gene family, such as HCN1, play a crucial role in the regulation of cell excitability. Importantly, they contribute to spontaneous rhythmic activity in both the heart and brain.1

1 Zong, X., Eckert, C., Yuan, H., et al. A novel mechanism of modulation of hyperpolarization-activated cyclic nucleotide-gated channels by src kinase. J Biol Chem 280(40) 34224-34232 (2005).

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