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Cat. Number
652656184195944
Chemical Name
9(S)-HODE-d4
References
Formal Name 9S-​hydroxy-​10E,​12Z-​octadecadienoic-​9,​10,​12,​13-​d4 acid
Molecular Formula C18H28D4O3
Formula Weight 300.5
Formulation A solution in ethanol
Purity >99% deuterated product
λmax 234 nm
ε 23
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES CCCCC/C=CC=C[C@@H]​(O)​CCCCCCCC(=O)​O

Background Reading

Gardner, H.W. Soybean lipoxygenase-1 enzymically forms both (9S)- and (13S)-hydroperoxides from linoleic acid by a pH-dependent mechanism. Biochim Biophys Acta 1001 274-281 (1989).

Kühn, H., Belkner, J., and Wiesner, R. Subcellular distribution of lipoxygenase products in rabbit reticulocyte membranes. Eur J Biochem 191 221-227 (1990).

Lo, H., Bartek, G.A., and Fischer, S.M. In vitro activation of mouse skin protein kinase C by fatty acids and their hydroxylated metabolites. Lipids 29 547-553 (1994).

Size Global Purchasing
25 µg  
50 µg  
100 µg  
500 µg  

Description

9(S)-HODE-d4 contains four deuterium atoms at the 9, 10, 12, and 13 positions. It is intended for use as an internal standard for the quantification of 9(S)-HODE by GC- or LC-mass spectrometry. 9(S)-HODE is produced by the lipoxygenation of linoleic acid in both plants and animals.1,2 It has been detected in atherosclerotic plaques, as an esterified component of membrane phospholipids and in oxidized low-density lipoproteins particles.3

1 Gardner, H.W. Soybean lipoxygenase-1 enzymically forms both (9S)- and (13S)-hydroperoxides from linoleic acid by a pH-dependent mechanism. Biochim Biophys Acta 1001 274-281 (1989).

2 Kühn, H., Belkner, J., and Wiesner, R. Subcellular distribution of lipoxygenase products in rabbit reticulocyte membranes. Eur J Biochem 191 221-227 (1990).

3 Lo, H., Bartek, G.A., and Fischer, S.M. In vitro activation of mouse skin protein kinase C by fatty acids and their hydroxylated metabolites. Lipids 29 547-553 (1994).

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