| References |
| Formal Name |
15S-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic-5,6,8,9,11,12,14,15-d8 acid |
| CAS Number |
84807-87-4 |
| Molecular Formula |
C20H24D8O3 |
| Formula Weight |
328.5 |
| Formulation |
A solution in acetonitrile |
| Purity |
≥99% deuterated product |
| λmax |
236 nm |
| ε |
27 |
| Stability |
1 year |
| Storage |
-20°C |
| Shipping |
Wet ice
in continental US; may vary elsewhere
|
| SMILES |
CCCCC[C@H](O)C=CC=CC/C=CC/C=CCCCC(=O)O
|
Background Reading
Nadel, J.A., Conrad, D.J., Ueki, I.F., et al. Immunocytochemical localization of arachidonate 15-lipoxygenase in erythrocyes, leukocytes, and airway cells. J Clin Invest 87 1139-1145 (1991).
Ramis, I., Roselló-Catafau, J., Bulbena, O., et al. 15-Hydroxyeicosatetraenoic acid as a major eicosanoid in nasal secretions: Assay by high-performance liquid chromatographic-radioimmunoassay and gas chromatographic-mass spectrometric procedures. J Chromatogr 496 416-422 (1989).
Funk, M.O., Carroll, R.T., Thompson, J.F., et al. The lipoxygenases in developing soybean seeds, their characterization and synthesis in vitro. Plant Physiol 82 1139-1144 (1986).
| Size |
Global Purchasing |
| 25 µg |
|
| 50 µg |
|
| 100 µg |
|
| 500 µg |
|
Description
15(S)-HETE-d8 contains eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14, and 15 positions. It is intended for use as an internal standard for the quantification of 15(S)-HETE by GC- or LC-MS. 15(S)-HETE is a major arachidonic acid metabolite from the 15-lipoxygenase pathway. In mammals, 15(S)-HETE is synthesized in the respiratory epithelium, leukocytes, and reticulocytes.1 15(S)-HETE is present in µg/ml concentrations in the nasal secretions of allergic rhinitis.2
1
Nadel, J.A., Conrad, D.J., Ueki, I.F., et al. Immunocytochemical localization of arachidonate 15-lipoxygenase in erythrocyes, leukocytes, and airway cells. J Clin Invest 87 1139-1145 (1991).
2
Ramis, I., Roselló-Catafau, J., Bulbena, O., et al. 15-Hydroxyeicosatetraenoic acid as a major eicosanoid in nasal secretions: Assay by high-performance liquid chromatographic-radioimmunoassay and gas chromatographic-mass spectrometric procedures. J Chromatogr 496 416-422 (1989).
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