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| Cat. Number | A5281 |
| Chemical Name | Angiotensin II (4-8), human |
| Mol. Formula | C35H45N7O7 |
| Mol. Weight | 675.79 |
| Application Notes | ≥95% |
| Solubility | Soluble in water. |
| Storage condition | -20°C |
| References | Angiotensin II (AT II) is a peptide produced from AT I by angiotensin-converting-enzyme (ACE). AT II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca2+ levels; this results in contraction and vasoconstriction, increasing blood pressure. AT II also acts at the Na+/H+ exchanger in the proximal tubules of the kidney. Here, AT II increases reabsorption of Na+ and HCO3- and excretion of H+, increasing blood volume and pH and further increasing blood pressure. |
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