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| Cat. Number | 288238893734858 |
| Chemical Name | AZ 3146 |
| CAS Number | [1124329-14-1] |
| Mol. Formula | C24H32N6O3 |
| Mol. Weight | 452.55 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Synonym | 9-Cyclopentyl-2-[[2-methoxy-4-[(1-m ethylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7, 9-dihydro-8H-purin-8-one |
| Solubility | Soluble to 25 mM in DMSO and to 75 mM in ethanol |
| Storage condition | Store at +4°C |
| References | Potent and selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 35 nM). Displays selectivity over 46 other kinases including Cdk1 and aurora kinase B. Interferes with chromosome alignment and overrides spindle assembly checkpoint. Inhibits the recruitment of Mad1, Mad2 and centromere protein E (CENP-E) to kinetochores. Purity: >99 % |
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