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| Cat. Number | 284749919139931 |
| Chemical Name | BIBX 1382 dihydrochloride |
| CAS Number | [196612-93-8] |
| Mol. Formula | C18H19ClFN7.2HCl |
| Mol. Weight | 460.77 |
| Qty 1 |
1mg |
| Qty 2 | 10mg |
| Synonym | N8-(3-Chloro-4-fluorophenyl)-N2-(1- methyl-4-piperidinyl)-pyrimido[5,4-d]pyrimidine-2, 8-diamine dihydrochloride |
| Solubility | Soluble to 50 mM in water and to 50 mM in DMSO |
| Storage condition | Desiccate at +4°C |
| References | Potent, selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 3 nM). Displays > 1000-fold lower potency against ErbB2 (IC50 = 3.4 μM) and a range of other related tyrosine kinases (IC50 > 10 μM). Oral administration inhibits growth of established human xenografts in athymic mice. Purity: >98 % |
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