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| Cat. Number | 283785825940281 |
| Chemical Name | Cucurbitacin I |
| CAS Number | [2222-07-3] |
| Mol. Formula | C30H42O7 |
| Mol. Weight | 514.65 |
| Qty 1 |
1mg |
| Synonym | (9β,10α,16α,23E)-2,16,20,25-Tetrahydro xy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-tr ione |
| Solubility | Soluble to 10 mM in DMSO and to 20 mM in ethanol |
| Storage condition | Store at -20°C |
| References | Selective inhibitor of STAT3/JAK2 signaling. Inhibits the activation of STAT3 and JAK2 and displays no activity on Src, Akt, ERK and JNK. Suppresses phosphotyrosine levels of STAT3, inhibits STAT3 DNA binding and STAT3-mediated gene expression. Induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3. Purity: >98 % |
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