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| Cat. Number | 279514853430129 |
| Chemical Name | Dorsomorphin dihydrochloride |
| CAS Number | [866405-64-3] |
| Mol. Formula | C24H25N5O.2HCl |
| Mol. Weight | 472.41 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Synonym | 6-[4-[2-(1-Piperidinyl)ethoxy]pheny l]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine dihydrochloride |
| Solubility | Soluble to 100 mM in water and to 10 mM in DMSO |
| Storage condition | Desiccate at RT |
| References | Potent and selective inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM). Displays no significant activity on several structurally related kinases including ZAPK, SYK, PKCθ, PKA and JAK3. Inhibits AMPK activation induced by AICAR (Cat. No. 2840) and metformin (Cat. No. 2864). Also inhibits bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6). Promotes cardiomyogenesis in mouse embryonic stem cells (ESCs) in vitro. Purity: >98 % |
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