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| Cat. Number | Eeyarestatin I |
| Chemical Name | Eeyarestatin I |
| CAS Number | [412960-54-4] |
| Mol. Formula | C27H25Cl2N7O7 |
| Mol. Weight | 630.44 |
| Qty 1 |
10mg |
| Synonym | 3-(4-Chlorophenyl)-4-[[[(4-chloroph enyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-o xo-1-imidazolidineacetic acid 2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydraz ide |
| Solubility | Soluble to 100 mM in DMSO |
| Storage condition | Desiccate at +4°C |
| References | Potent inhibitor of endoplasmic reticulum associated protein degradation (ERAD). Specifically targets the p97-associated deubiquinating process (PAD) and inhibits ataxin-3 (atx3)-dependent deubiquitination. Also inhibits Sec61-mediated protein translocation at the ER. Displays cytotoxic activity preferentially against cancer cells; induces cell death via the proapoptotic protein NOXA. Purity: >98 % |
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