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| Cat. Number | GW 583340 dihydrochloride |
| Chemical Name | GW 583340 dihydrochloride |
| CAS Number | [388082-81-3] |
| Mol. Formula | C28H25ClFN5O3S2.2HCl |
| Mol. Weight | 671.03 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Synonym | N-[3-Chloro-4-[(3-fluorophenyl)meth oxy]phenyl]-6-[2-[[[2-(methylsulfonyl)ethyl]amino] methyl]-4-thiazolyl]-4-quinazolinamine dihydrochloride |
| Solubility | Soluble to 100 mM in DMSO |
| Storage condition | Desiccate at +4°C |
| References | Potent dual EGFR/ErbB2 tyrosine kinase inhibitor (IC50 values are 0.01 and 0.014 μM respectively). Selectively inhibits growth of human tumor cells overexpressing EGFR and ErbB2 (IC50 values are 0.11 μM for inhibition of HN5, N87 and BT474 tumor cell lines vs. > 30 μM for inhibition of non-tumor cell line HFF). Inhibits tumor growth in vivo by ~ 80% in a murine xenograft model following oral administration. Purity: >97 % |
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