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| Cat. Number | GW 405833 |
| Chemical Name | GW 405833 |
| CAS Number | [180002-83-9] |
| Mol. Formula | C23H24Cl2N2O3 |
| Mol. Weight | 447.36 |
| Qty 1 |
10mg |
| Appearance | Off-White Solid |
| Application Notes | >98 % |
| Synonym | L-768,242 1-(2,3-Dichlorobenzoyl)-5-methoxy-2 -methyl-3-[2-(4-morpholinyl)ethyl]-1H-indole |
| Melting Pt. | 115 - 118°C |
| Solubility | Soluble to 50 mM in DMSO and to 50 mM in ethanol |
| Storage condition | Store at RT |
| References |
Potent and selective CB2 receptor partial agonist (EC50 = 0.65 nM; maximum inhibition = 44.6%). Binds with high affinity to both human and rat CB2 receptors and displays ~ 1200-fold selectivity over CB1 (Ki values are 3.92 and 4772 nM for human recombinant CB2 and CB1 receptors respectively). Produces potent antihyperalgesic effects in several rodent models of pain. |
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