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| Cat. Number | Gliotoxin |
| Chemical Name | Gliotoxin |
| CAS Number | [67-99-2] |
| Mol. Formula | C13H14N2O4S2 |
| Mol. Weight | 326.38 |
| Qty 1 |
1mg |
| Synonym | (3R,5aS,6S,10aR)-2,3,5a,6-Tetrahydr o-6-hydroxy-3-(hydroxymethyl)-2-methyl-10H-3,10a-e pidithiopyrazino[1,2-a]indole-1,4-dione |
| Solubility | Soluble in DMSO and in ethanol |
| Storage condition | Desiccate at -20°C |
| References | Immunosuppressive agent; blocks phagocytosis, cytokine production and proliferation of T and B cells. Non-competitively inhibits chymotrypsin-like activity of 20S proteasome; prevents degradation of IκBα, an endogenous blocker of NF-κB. Also inhibits farnesyltransferase and geranylgeranyltransferase I (IC50 values are 80 and 17 μM respectively) and displays antitumor activity against breast cancer in vivo. |
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