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Cat. Number
4-HQN
Chemical Name
4-HQN
CAS Number
[491-36-1]
Mol. Formula
C8H6N2O
Mol. Weight
146.15
Qty 1
50mg
Synonym
4-(1H)-Quinazolinone
Solubility
Soluble to 10 mM in water and to 100 mM in DMSO
Storage condition
Desiccate at RT
References
Inhibitor of poly(ADP-ribose) polymerase (PARP) (IC50 = 9.5 μM); displays mixed inhibition with respect to NAD+. Protective against ischemia-reperfusion induced ROS production, and subsequent mitochondrial and cell damage in rat heart. Anti-inflammatory in LPS-induced endotoxic mice in vivo; decreases NF-κB and AP-1 activation.
Purity: >99 %
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