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| Cat. Number | Kenpaullone |
| Chemical Name | Kenpaullone |
| CAS Number | [142273-20-9] |
| Mol. Formula | C16H11BrN2O |
| Mol. Weight | 327.18 |
| Qty 1 |
10mg |
| Synonym | 9-Bromo-7,12-dihydro-indolo[3,2-d][ 1]benzazepin-6(5H)-one |
| Solubility | Soluble to 100 mM in DMSO and to 5 mM in ethanol |
| Storage condition | Store at RT |
| References | Potent inhibitor of CDK1/cyclin B and GSK-3β (IC50 values are 0.4 and 0.23 μM respectively). Also inhibits CDK2/cyclin A, CDK2/cyclin E and CDK5/cyclin/p35 (IC50 values are 0.68, 7.5 and 0.85 μM respectively). Selective over c-src (IC50 = 15 μM), casein kinase 2 (IC50 = 20 μM), ERK1 (IC50 = 20 μM), ERK2 (IC50 = 9 μM) and a range of other protein kinases (IC50 values > 35 μM). Generates induced pluripotent stem cells (iPSCs) from somatic cells when used in combination with reprogramming factors; can replace Klf4. Purity: >98 % |
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