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| Cat. Number | LY 364947 |
| Chemical Name | LY 364947 |
| CAS Number | [396129-53-6] |
| Mol. Formula | C17H12N4 |
| Mol. Weight | 272.31 |
| Qty 1 |
1mg |
| Qty 2 | 10mg |
| Synonym | 4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl] -quinoline |
| Solubility | Soluble to 100 mM in DMSO |
| Storage condition | Store at RT |
| References | Selective inhibitor of TGF-β type-I receptor (TGF-β RI, TGFR-I, TβR-I, ALK-5) (IC50 values are 59, 400 and 1400 nM for TGR-β RI, TGF-β RII and MLK-7K respectively). Inhibits TGF-β-dependent luciferase production in mink lung cells (p3TP lux) and growth in mouse fibroblasts (NIH 3T3) (IC50 values are 47 and 89 nM respectively). Suppresses invasion of MDA-MB-231 breast cancer cells in a matrigel invasion assay. Purity: >99 % |
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