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| Cat. Number | Leflunomide |
| Chemical Name | Leflunomide |
| CAS Number | [75706-12-6] |
| Mol. Formula | C12H9F3N2O2 |
| Mol. Weight | 270.21 |
| Qty 1 |
50mg |
| Synonym | 5-Methyl-N-[4-(trifluoromethyl)phen yl]-4-isoxazolecarboxamide |
| Solubility | Soluble to 100 mM in ethanol and to 100 mM in DMSO |
| Storage condition | Store at +4°C |
| References | Immunosuppressive agent. The active metabolite A77 1726 (RS-61980) inhibits dihydroorotate dehydrogenase (Ki = 2.7 μM) and de novo pyrimidine synthesis in T-cells in vitro. Blocks lymphocyte cell cycle progression and proliferation. A77 1726 also inhibits anti-CD3/CD28-induced cytokine production in PBMC cells (IC50 = 21 - 27 μg/ml). Reduces inflammation in vivo including in several animal models of autoimmune disease, arthritis, asthma and graft rejection. Purity: >99 % |
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