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| Cat. Number | MRK 016 |
| Chemical Name | MRK 016 |
| CAS Number | [783331-24-8] |
| Mol. Formula | C17H20N8O2 |
| Mol. Weight | 368.39 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Synonym | 3-(1,1-Dimethylethyl)-7-(5-methyl-3 -isoxazolyl)-2-[(1-methyl-1H-1,2,4-triazol-5-yl)me thoxy]-pyrazolo[1,5-d][1,2,4]triazine |
| Solubility | Soluble to 100 mM in DMSO and to 10 mM in ethanol |
| Storage condition | Store at +4°C |
| References | GABAA receptor inverse agonist selective for the α5-subtype (EC50 = 3 nM). Exhibits affinity at benzodiazepine binding site of recombinant human GABAA receptors (Ki values are 0.77 nM, 0.83 nM, 0.85 nM and 1.4 nM for α3-, α1-, α2-, and α5-containing respectively). Increases long-term potentiation (LTP) in mouse hippocampal slices. Exhibits no anxiogenic or proconvulsant activity. Purity: >98 % |
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