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| Cat. Number | MK 886 |
| Chemical Name | MK 886 |
| CAS Number | [118414-82-7] |
| Mol. Formula | C27H34ClNO2S |
| Mol. Weight | 472.08 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Synonym | 1-[(4-Chlorophenyl)methyl]-3-[(1,1- dimethylethyl)thio]-α,α-dimethyl-5-(1-methylethyl)-1 H-Indole-2-propanoic acid |
| Solubility | Soluble to 5 mM in ethanol and to 100 mM in DMSO |
| Storage condition | Store at RT |
| References |
An inhibitor of leukotriene biosynthesis (IC50 = 3 nM in human polymorphonuclear leukocytes). Acts by inhibiting 5-lipoxygenase-activating protein (FLAP) (IC50 = 30 nM for inhibition of [125I]-L-691,678 photoaffinity labelling). Also moderately potent PPARα antagonist (IC50 = 0.5-1 μM). Orally active in vivo. |
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