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Cat. Number
M40
Chemical Name
M40
CAS Number
[143896-17-7]
Mol. Formula
C94H145N23O24
Mol. Weight
1981.33
Qty 1
1mg
Storage condition
Desiccate at -20°C
References
Potent, non-selective galanin receptor antagonist (Ki values are 1.82 and 5.1 nM at GAL1 and GAL2 respectively) that inhibits galanin (1-29) (Cat. No. 2696) binding in rat brain in vitro (IC50 = 3 - 15 nM). Attenuates the antidepressant effects of fluoxetine (Cat. No. 0927) and blocks galanin-induced food intake in vivo. Also exhibits weak partial agonist activity at peripheral GAL2 receptors at doses > 100 nM.
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