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| Cat. Number | nTZDpa |
| Chemical Name | nTZDpa |
| CAS Number | [118414-59-8] |
| Mol. Formula | C22H15Cl2NO2S |
| Mol. Weight | 428.33 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Synonym | 5-Chloro-1-[(4-chlorophenyl)methyl] -3-(phenylthio)-1H-indole-2-carboxylic acid |
| Solubility | Soluble to 100 mM in DMSO |
| Storage condition | Store at +4°C |
| References | Potent, selective non-thiazolidinedione PPARγ partial agonist (EC50 = 57 nM); produces ~25% maximum efficacy. Antagonizes full agonist activity by ~60% (IC50 ~ 285 nM). Displays no activity at PPARα or PPARδ receptors. Produces altered receptor conformation, and regulates adipocyte development and gene expression, in a differential manner to full PPARγ agonists. Modulates metabolism and insulin sensitivity without causing cardiac hypertrophy in mice in vivo. Purity: >98 % |
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