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| Cat. Number | NSC 663284 |
| Chemical Name | NSC 663284 |
| CAS Number | [383907-43-5] |
| Mol. Formula | C15H16ClN3O3 |
| Mol. Weight | 321.76 |
| Qty 1 |
10mg |
| Synonym | 6-Chloro-7-[[2-(4-morpholinyl)ethyl ]amino]-5,8-quinolinedione |
| Solubility | Soluble to 50 mM in DMSO and to 50 mM in ethanol |
| Storage condition | Store at +4°C |
| References | Potent, selective inhibitor of Cdc25 dual specificity phosphatases (Ki values are 29, 95 and 89 nM for human Cdc25A, Cdc25B2 and Cdc25C respectively); > 20- and > 450-fold selective over VHR and PTP1B phosphatases respectively. Arrests cells at both G1 and G2/M phase and blocks cdk2 and cdk1 activation. Blocks proliferation of a range of human tumor cell lines (IC50 = 0.2 - 35 μM). Purity: >99 % |
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