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Cat. Number
Nebivolol hydrochloride
Chemical Name
Nebivolol hydrochloride
CAS Number
[152520-56-4]
Mol. Formula
C22H25F2NO4.HCl
Mol. Weight
441.9
Qty 1
10mg
Qty 2
50mg
Synonym
(±)-[2R*(1S*5S*(S*))]-α,α'-[Iminobis(me thylene)bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2 -methanol)
Solubility
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Storage condition
Desiccate at RT
References
Highly selective β1-adrenoceptor antagonist (Ki values are 0.88, 20, 44, 700, 1160, 2400 and 4000 nM at β1, 5-HT1A, β2, 5-HT2, α1, H1 and D2 receptors respectively). Induces vasodilation via a nitric oxide- and cGMP-dependent mechanism (EC50 = 11.36 μM in renal arteries) and displays antihypertensive activity in vivo.
Purity: >98 %
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