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| Cat. Number | (5Z)-7-Oxozeaenol |
| Chemical Name | (5Z)-7-Oxozeaenol |
| CAS Number | [66018-38-0] |
| Mol. Formula | C19H22O7 |
| Mol. Weight | 362.37 |
| Qty 1 |
1mg |
| Synonym | (3S,5Z,8S,9S,11E)-3,4,9,10-tetrahyd ro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benz oxacyclotetradecin-1,7(8H)-dione |
| Solubility | Soluble to 25 mM in DMSO and to 10 mM in ethanol |
| Storage condition | Desiccate at -20°C |
| References | Resorcyclic lactone of fungal origin that acts as a potent and selective transforming growth factor-β-activated kinase 1 (TAK1) mitogen-activated protein kinase kinase kinase (MAPKKK) inhibitor (IC50 = 8 nM). Displays > 33-fold and > 62-fold selectivity over MEKK1 and MEKK4 respectively. Inhibits IL-1-induced activation of NF-κB (IC50 = 83 nM) and JNK/p38. Inhibits production of inflammatory mediators, and sensitizes cells to TRAIL- and TNF-α-induced apoptosis in vitro. Purity: >99 % |
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