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| Cat. Number | PF 915275 |
| Chemical Name | PF 915275 |
| CAS Number | [857290-04-1] |
| Mol. Formula | C18H14N4O2S |
| Mol. Weight | 350.39 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Synonym | N-(6-Amino-2-pyridinyl)-4'-cyano-[1, 1'-biphenyl]-4-sulfonamide |
| Solubility | Soluble to 100 mM in DMSO |
| Storage condition | Store at RT |
| References | Potent and selective 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) inhibitor (Ki = 2.3 nM) that displays little activity at 11βHSD2 (1.5% inhibition at 10 μM). Inhibits the conversion of prednisone to prednisolone in human hepatocytes in vitro (EC50 = 15 nM) and has antidiabetic activity in vivo. Orally active. Purity: >98 % |
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