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| Cat. Number | PD 158780 |
| Chemical Name | PD 158780 |
| CAS Number | [171179-06-9] |
| Mol. Formula | C14H12BrN5 |
| Mol. Weight | 330.18 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Synonym | N4-(3-Bromophenyl)-N6-methyl-pyrido [3,4-d]pyrimidine-4,6-diamine |
| Solubility | Soluble to 100 mM in DMSO and to 25 mM in ethanol |
| Storage condition | Store at -20°C |
| References | Potent inhibitor of ErbB receptor family tyrosine kinases (IC50 values are 0.008, 49 and 52 nM for EGFR, ErbB2 and ErbB2/ErbB4 respectively) that does not inhibit FGF or PDGF-mediated tyrosine phosphorylation. Induces G1 cell cycle arrest in MCF10A cells and is antiproliferative in A431 human epidermal carcinoma cells. Purity: >99 % |
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