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| Cat. Number | RWJ 67657 |
| Chemical Name | RWJ 67657 |
| CAS Number | [215303-72-3] |
| Mol. Formula | C27H24FN3O |
| Mol. Weight | 425.5 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Synonym | 4-[4-(4-Fluorophenyl)-1-(3-phenylpr opyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1- ol |
| Solubility | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| Storage condition | Store at RT |
| References | Selective p38α and p38β inhibitor (IC50 values are 1 and 11 μM respectively) that displays no activity at p38γ, p38δ and a range of other kinases. Potently inhibits TNF-α and IL-1β release (IC50 values are 3 and 11 nM respectively) and suppresses HIV-1 replication in T-cells in vitro. Displays cardioprotective and anti-inflammatory activity in vivo. Orally active. Purity: >98 % |
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