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| Cat. Number | Rottlerin |
| Chemical Name | Rottlerin |
| CAS Number | [82-08-6] |
| Mol. Formula | C30H28O8 |
| Mol. Weight | 516.55 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Synonym | 3'-[(8-Cinnamoyl-5,7-dihydroxy-2,2-d imethyl-2H-1-benzopyran-6-yl)methyl]-2',4',6'-trihydr oxy-5'-methylacetophenone |
| Solubility | Soluble to 2 mM in ethanol and to 100 mM in DMSO |
| Storage condition | Store at +4°C |
| References | Originally reported to inhibit PKC isoforms, with selectivity for PKCδ (Ki values are 30, 42, 40, 3-6, 100, and 100 μM for α, β, γ, δ, ε, λ respectively). Also reported to inhibit CAM kinase III. However, recently shown to inhibit a wide range of protein kinases, and most potently to inhibit PRAK and MAPKAP-K2 (IC50 values are 1.9 and 5 μM respectively). Also shown to act as a direct mitochondrial uncoupler. |
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