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| Cat. Number | Ro 106-9920 |
| Chemical Name | Ro 106-9920 |
| CAS Number | [62645-28-7] |
| Mol. Formula | C10H7N5OS |
| Mol. Weight | 245.26 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Synonym | 6-(Phenylsulfinyl)tetrazolo[1,5-b]p yridazine |
| Solubility | Soluble to 5 mM in ethanol and to 100 mM in DMSO |
| Storage condition | Store at +4°C |
| References | Inhibitor of NF-κB activation, possibly via selective inhibition of LPS- and TNF-α-induced IκBα ubiquitination (IC50 = 3 μM). Blocks subsequent production of TNF-α, IL-1β and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo. Also weakly inhibits EGFR, 5-lipoxygenase and iNOS. Purity: >99 % |
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