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| Cat. Number | Ro 08-2750 |
| Chemical Name | Ro 08-2750 |
| CAS Number | [37854-59-4] |
| Mol. Formula | C13H10N4O3 |
| Mol. Weight | 270.24 |
| Qty 1 |
1mg |
| Qty 2 | 50mg |
| Synonym | 2,3,4,10-Tetrahydro-7,10-dimethyl-2 ,4-dioxobenzo[g]pteridine-8-carboxaldehyde |
| Solubility | Soluble to 50 mM in 1eq. NaOH and to 10 mM in DMSO |
| Storage condition | Store at -20°C |
| References | Non-peptide inhibitor of NGF that binds the NGF dimer (KD ~ 1 μM) possibly causing a conformational change. Inhibits binding selectively to p75NTR at submicromolar concentrations and to both p75NTR and TrkA at higher concentrations (> 5 μM). Prevents NGF-induced apoptosis in SK-N-MC cells. Purity: >96 % |
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